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  5. STEMCELL Technologies Ionomycin

STEMCELL Technologies Ionomycin

Product Code. 17180262
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Product Code. 17180262 Supplier STEMCELL Technologies Supplier No. 73722

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Description

Calcium ionophore

  • Ionomycin is a potent and selective calcium ionophore derived from Streptomyces conglobatus (Liu et al.) It is used as a research tool to rapidly raise the intracellular level of calcium, and to study calcium transport across biological membranes by inducing the release of cytosolic calcium stores (Morgan & Jacob; Yoshida & Plant)
  • Ionomycin is a more effective Ca++ ionophore than A23187, but less effective at binding and carrying Mg++ (Liu & Hermann)
  • Ionomycin is able to activate and prime the polymorphonuclear neutrophil (PMN) oxidase (Elzi et al.), and is used in conjunction with Phorbol 12-myristate 13-acetate (PMA; Catalog #74042) for the activation of T cells (IC50 = 5.8 nM; Caraher et al.; Zhang et al.) This product is supplied as a 10 mg/mL solution in ethanol
  • Activates T cells from human, mouse, or rat sources, in combination with PMA, to express cytokines including IL-17, IL-4, IL-10, and IL-2 (Caraher et al.; Harrington et al.; Parrish-Novak et al.)

Specifications

CAS 56092-81-0; 64-17-5
Synonym SQ 23377
Quantity 1 mg
Molecular Formula C41H72O9
Purity ≥98%
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