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Invitrogen™ IRAK-M Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA521559
This item is not returnable.
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Description
Recommended positive controls: DDDDK-tagged IRAK3-transfected 293T. Predicted reactivity: Mouse (80%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.
Specifications
| IRAK-M | |
| Polyclonal | |
| Unconjugated | |
| IRAK3 | |
| 4833428C18Rik; AI563835; ASRT5; FLJ13601; IL-1 receptor-associated kinase M; interleukin 1 receptor associated kinase 3; interleukin-1 receptor-associated kinase 3; IRAK3; IRAK-3; IRAKM; IRAK-M | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 11213 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 0.22 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| Q9Y616 | |
| IRAK3 | |
| Recombinant protein encompassing a sequence within the center region of human IRAK3. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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