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Invitrogen™ IRAK-M Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA589217
This item is not returnable.
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Description
Immunogen sequence: VLTGCRVVLD DPKHIQLRDL LRELMEKRGL DSCLSFLDKK VPPCPRNFSA KLFCLAGRCA ATRAKLRPSM DEVLNTLEST QASLYFAEDP PTSLKSFRCP SPLFLENVPS IPVEDDESQN NNLLPSDEGL RIDRMTQKTP FECSQSEVMF LSLDKKPESK RNEEACNMPS SSCEESWFPK YIVPSQDLRP YKVNIDPSSE APGHSCRSRP VESSCSSKFS WDEYEQYKKE; Positive Samples: HL-60, THP-1, Mouse lung, Rat lung.
IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.
Specifications
| IRAK-M | |
| Polyclonal | |
| Unconjugated | |
| IRAK3 | |
| 4833428C18Rik; AI563835; ASRT5; FLJ13601; IL-1 receptor-associated kinase M; interleukin 1 receptor associated kinase 3; interleukin-1 receptor-associated kinase 3; IRAK3; IRAK-3; IRAKM; IRAK-M | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 11213, 314870, 73914 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry | |
| 2.24 mg/mL | |
| PBS with 50% glycerol and 0.09% sodium azide; pH 7.3 | |
| Q8K4B2, Q9Y616 | |
| IRAK3 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 367-596 of human IRAK3 (NP_0091302). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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