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Invitrogen™ IRF4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA587447
This item is not returnable.
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Description
Immunogen sequence: HPYTMTTPYP SLPAQQVHNY MMPPLDRSWR DYVPDQPHPE IPYQCPMTFG PRGHHWQGPA CENGCQVTGT FYACAPPESQ APGVPTEPSI RSAEALAFSD CRLHICLYYR EILVKELTTS SPEGCRISHG HTYDASNLDQ VLFPYPEDNG QRKNIEKLLS HLERGVVLWM APDGLYAKRL CQSRIYWDGP LALCNDRPNK L; Positive Samples: Mouse spleen, Mouse lung, Rat spleen, Rat lung, Rat thymus; Cellular Location: Nucleus.
The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
Specifications
| IRF4 | |
| Polyclonal | |
| Unconjugated | |
| IRF4 | |
| AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 16364, 3662 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot | |
| 0.57 mg/mL | |
| PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
| Q15306, Q64287 | |
| IRF4 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human IRF4 (NP_0024512). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
Product Title
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