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Invitrogen™ ITFG2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5103447
This item is not returnable.
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Description
Antibody detects endogenous levels of total ITFG2.
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Specifications
| ITFG2 | |
| Polyclonal | |
| Unconjugated | |
| ITFG2 | |
| 2700050P07Rik; AI646725; integrin alpha FG-GAP repeat containing 2; integrin-alpha FG-GAP repeat-containing protein 2; integrin-alpha FG-GAP repeat-containing protein 2; KICSTOR complex protein ITFG2; ITFG2; KICSTOR complex protein ITFG2; MDS028; RGD1311944 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 101142, 55846 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q91WI7, Q969R8 | |
| ITFG2 | |
| A synthesized peptide derived from human ITFG2(Accession Q969R8), corresponding to amino acid residues L198-R248. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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