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ITGB3BP Monoclonal Antibody (OTI4H1), TrueMAB™, OriGene

Product Code. 17532543
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17532543 100 μL 100µL
17552543 30 μL 30µL
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Product Code. 17532543 Supplier Origene Technologies Supplier No. TA803458

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Description

Mouse Monoclonal Antibody

ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Specifications

Antigen ITGB3BP
Applications Western Blot
Classification Monoclonal
Clone OTI4H1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene ITGB3BP
Gene Accession No. Q13352
Gene Alias CENP-R, CENPR, HSU37139, NRIF3, TAP20
Gene Symbols ITGB3BP
Host Species Mouse
Immunogen Full length human recombit protein of human ITGB3BP produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23421
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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