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Invitrogen™ KCNH2 Polyclonal Antibody
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Product Code. 15372781
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50 μg
Unit Size:
50µg
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15372781 50 μg 50µg
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Product Code. 15372781 Supplier Invitrogen™ Supplier No. PA533867

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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse, Rabbit, Pig (100%).

Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNH2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene KCNH2
Gene Accession No. O08962, O35219, Q12809, Q8WNY2, Q9TSZ3, Q9TUI4
Gene Alias AI326795; cerg; c-ERG; cERG; ether-a-go-go related member 2; delayed rectifier potassium channel; derg; Eag homolog; eag related protein 1; eag-related gene; eag-related protein 1; ERG; ERG1; ERG-1; ether-a-go-go related gene potassium channel 1; ether-a-go-go related protein; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; ether-a-go-go-related protein 1; gp-erg; HERG; H-ERG; HERG1; HERG-1; KCNH2; Kv11.1; LQT; Lqt2; M-erg; Merg1; M-erg1; merg1a; merg1b; potassium channel; potassium channel protein ERG; potassium channel protein ERG long isoform; potassium channel protein ERG short isoform; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ra-erg; RERG; r-ERG; SQT1; ventricular ERG K+ channel subunit; voltage-gated potassium channel 11.1; voltage-gated potassium channel subunit Kv11.1; voltage-gated potassium channel variant 3; voltage-gated potassium channel, subfamily H, member 2
Gene Symbols KCNH2
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from internal region of human KCNH2 / Kv11.1.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009242, 100064000, 100523293, 100770245, 117018, 16511, 3757, 403761, 539971
Target Species Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Horse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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