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Invitrogen™ KCTD4 Monoclonal Antibody (2C8)

Mouse Monoclonal Antibody

Brand: Invitrogen™ MA523295

Product Code. 15533212

€ 520.00 / 100µg

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Description

Peptide Sequence: MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIRFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV HSDALHFIK.

The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.

Specifications

Antigen	KCTD4
Classification	Monoclonal
Concentration	1.0 mg/mL
Formulation	PBS with no preservative; pH 7.4
Gene Accession No.	Q8WVF5
Gene Symbols	KCTD4
Immunogen	KCTD4 (AAH18063, 1 a.a. ~ 259 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Quantity	100 μg
Primary or Secondary	Primary
Target Species	Human
Product Type	Antibody
Isotype	IgG2b κ

Applications	ELISA, Western Blot
Clone	2C8
Conjugate	Unconjugated
Gene	KCTD4
Gene Alias	bA321C24.3; BTB/POZ domain-containing protein KCTD4; KCTD4; potassium channel tetramerisation domain containing 4; potassium channel tetramerization domain containing 4
Host Species	Mouse
Purification Method	Affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	386618
Content And Storage	-20°C, Avoid Freeze/Thaw Cycles
Form	Liquid

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Invitrogen™ KCTD4 Monoclonal Antibody (2C8)

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