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Invitrogen™ KLF15 Polyclonal Antibody
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Product Code. 16579441
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Quantity:
100 μL
Unit Size:
100µL
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16579441 100 μL 100µL
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Product Code. 16579441 Supplier Invitrogen™ Supplier No. PA596606

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ LLVNIQGQTF; Positive Samples: BT-474; Cellular Location: Nucleus.

KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KLF15
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.34 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KLF15
Gene Accession No. Q9UIH9
Gene Alias 1810013I09Rik; AV048136; AW494632; Cardiovascular Krueppel-like factor; CKLF; DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF; KKLF protein; Klf15; KLF15; transcription factor; Krueppel-like factor 15; Kruppel like factor 15; Kruppel-like factor 15
Gene Symbols KLF15
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human KLF15 (NP_0547981).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28999
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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