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Invitrogen™ KSR1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5102915
This item is not returnable.
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Description
Antibody detects endogenous levels of total KSR1.
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt].
Specifications
| KSR1 | |
| Polyclonal | |
| Unconjugated | |
| KSR1 | |
| AW492498; B-KSR1; CAP kinase; D11Bhm183e; D11Bhm184e; hb; HB protein; kinase KSR1; Kinase suppressor of Ras 1; Ksr; KSR1; mKSR1; OTTHUMP00000162931; protein Hb; RSU2 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 16706, 360573, 8844 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q61097, Q8IVT5 | |
| KSR1 | |
| A synthesized peptide derived from human KSR1(Accession Q8IVT5), corresponding to amino acid residues R544-R594. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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