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Tocris Bioscience™ KU 0060648
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Product Code. 30001690
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30001690 10 mg 10mg
30001528 50 mg 50mg
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Product Code. 30001690 Supplier Tocris Bioscience™ Supplier No. 4840/10

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Description

Dual DNA-PK and PI 3-K inhibitor

Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ∽2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ∽40%; maximum effect seen at 250 nM.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 881375-00-4
Molecular Formula C33H34N4O4S

Specifications

Quantity 10 mg
Formula Weight 582.71
Purity >97%
Molecular Weight (g/mol) 582.719
Chemical Name or Material KU 0060648
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