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Invitrogen™ L-Plastin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA530078

Product Code. 13454617

  • € 520.00 / 100µL

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Description

Description

Recommended positive controls: A431, Jurkat, Raji. Predicted reactivity: Human (99%), Mouse (95%), Rat (94%), Zebrafish (84%), Xenopus laevis (89%), Chicken (90%), Rhesus Monkey (99%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

L-Plastin
Polyclonal
Unconjugated
LCP1
65 kDa macrophage protein; AW536232; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); cb245; CP64; D14Ertd310e; DKFZp781A23186; epididymis secretory protein Li 37; fj24b12; FLJ25423; FLJ26114; FLJ39956; HEL-S-37; LC64P; LCP1; LCP-1; leucocyte-specific plastin 1; L-fimbrin; LPL; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); lymphocyte cytosolic plastin 1; lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; plastin-2; Pls2; pp65; wu:fj24b12
Rabbit
Antigen affinity chromatography
RUO
3936
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.4 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P13796
LCP1
Recombinant protein encompassing a sequence within the center region of human L-Plastin. The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
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