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Thermo Scientific™ Lab Vision™ p57 Kip2 Ab-6, Mouse Monoclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-6, Mouse Monoclonal Antibody.

Merk:  Thermo Scientific™ MS-1062-P1ABX

Overige gegevens : Gewicht : 1.00000kg

 Bekijk meerdere types van dit product via de

Produktcode. 12688776

  • € 394.00 / 100 µL


Geschatte verzenddatum
bij leverancier 25-07-2019
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Beschrijving

Beschrijving

p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Mouse

Clone: 57P06; same as KP10

Isotype: IgG2b/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: Not determined

Immunogen: Recombinant human p57Kip2 protein

Molecular Weight: 57kDa

Positive Control: LS174T cells, Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not suitable)
  • Immunoprecipitation (Native verified)
Specificatie

Specificatie

p57superscriptKip2superscript Ab-6
Monoclonal
1mg/mL
Ab without BSA/Azide (Frozen)
Murine
IgG2b kappa
IVD
Primary
Monoclonal
Immunohistochemistry (Paraffin), Immunoprecipitation
57P06 ;same as KP10
Unconjugated
Concentrated
Recombinant human p57superscriptKip2superscript protein
100μL
Cell Cycle
Primary
Human, Murine
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