Renal Cell Carcinoma Marker (gp200) Ab-1 Mouse Monoclonal Antibody, Epredia™

Description

In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Of other normal tissues examined, the gp200 is also localized along the luminal surfaces of breast lobules and ducts, the luminal surface of the epididymal tubular epithelium, within the cytoplasm of parathyroid parenchymal cells, and focally within the colloid of thyroid follicles. Thirty-one other normal tissues do not express similar or cross-reacting antigens. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas.

Host Species: Mouse

Clone: PN-15

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: Carbohydrate domain

Immunogen: Microsomal fraction of human renal cortical tissue homogenate

Molecular Weight: ∽200kDa

Positive Control: Normal kidney or renal cell CA

Cellular Localization: Membrane and cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting (Reduced and nonreduced)