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LAG3 Monoclonal Antibody (OTI10E7), TrueMAB™, OriGene

Product Code. 17507513
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100 μL
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30µL
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17507513 100 μL 100µL
17527513 30 μL 30µL
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Product Code. 17507513 Supplier Origene Technologies Supplier No. TA807146

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Description

Mouse Monoclonal Antibody

CD-223 (LAG-3, Lymphocyte-activation protein 3) is a 70 kDa surface glycoprotein belonging to the Ig superfamily. CD-223 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of CD-223 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express CD-223 at significantly higher levels than CD4+ T cells. Coexpression of CD-223 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells). LAG-3 contains 4 extracellular Ig-like domains and its gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate homology of CD-223 to CD4.

Specifications

Antigen LAG3
Applications Western Blot
Classification Monoclonal
Clone OTI10E7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene LAG3
Gene Accession No. P18627
Gene Alias CD223
Gene Symbols LAG3
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 66-332 of human LAG3 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3902
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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