Invitrogen™ Lamin B2 Monoclonal Antibody (LN43)

Description

MA1-06104 detects lamin B2 in human, mouse, porcine, Xenopus laevis, zebrafish and hamster samples. MA1-06104 has sucessfully been used in FACS, immunohistochemistry, and Western blotting procedures. The MA1-06104 immunogen is a detergent insoluble fraction of potoroo cell line PtK1. Store at 4°C, or in small aliquots at -20°C.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.