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Invitrogen™ Laminin beta-2/gamma-1 Monoclonal Antibody (M046)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA547722
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Description
Clone M046 detects native laminin isoforms that include both laminin beta2 and gamma1 subunits. In native immunoblots, the antibody detects laminin 521, laminin 221, and laminin 121, but does not detect lamin 332 and laminin 411. The antibody weakly detects laminin 511. This antibody can be used for immunocytochemical detection of laminin beta2/gamma1 subunits, and can also be used for detection of native laminin isoforms in immunoblots and ELISA.
Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
Specifications
| Laminin beta-2/gamma-1 | |
| Monoclonal | |
| ~1.0 mg/mL | |
| PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
| P11047, P55268 | |
| LAMB2, LAMC1 | |
| Clone (M046) was generated from a recombinant human laminin 521 protein that includes a heterotrimer of three subunits laminin alpha5, laminin beta2, and laminin gamma1 subunits. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Western Blot, Immunocytochemistry | |
| M046 | |
| Unconjugated | |
| LAMC1 | |
| AA408497; AW211941; B2e; basement membrane protein; Lama; Lamb2; Lamb-2; Lamc1; Laminin B1s chain; laminin B2 chain; laminin beta 2; laminin beta 2 chain; laminin chain B3; laminin chain beta 2; laminin gamma 1 chain; Laminin S; laminin subunit beta 2; laminin subunit beta-2; laminin subunit gamma 1; laminin subunit gamma-1; laminin, beta 2; laminin, beta 2 (laminin S); laminin, gamma 1; laminin, gamma 1 (formerly LAMB2); laminin-1 subunit gamma; Laminin-10 subunit gamma; laminin-11 subunit beta; Laminin-11 subunit gamma; laminin-14 subunit beta; Laminin-15 subunit beta; laminin-2 subunit gamma; Laminin-3 subunit beta; laminin-3 subunit gamma; Laminin-4 subunit beta; laminin-4 subunit gamma; Laminin-6 subunit gamma; laminin-7 subunit beta; Laminin-7 subunit gamma; laminin-8 subunit gamma; Laminin-9 subunit beta; laminin-9 subunit gamma; LAMS; NPHS5; npht; SLAM; S-LAM beta; S-LAM gamma; S-laminin subunit beta; S-laminin subunit gamma | |
| Mouse | |
| Protein G | |
| RUO | |
| 3913, 3915 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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