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Invitrogen™ Laminin Polyclonal Antibody
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Product Code. 11555363
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100 μL
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100µL
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11555363 100 μL 100µL
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Product Code. 11555363 Supplier Invitrogen™ Supplier No. PA116730

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Description

Rabbit Polyclonal Antibody

This antibody is pan-specific and reacts well with all Laminin isoforms tested: Laminin-1 (alpha-1, beta-1, and gamma-1) and Laminin-2 (alpha-2, beta-1, and gamma-1). The antibody functionally inhibits Laminin in mouse and rat. It binds to Laminin and inhibits most, if not all, of its cell adhesion and growth promotive properties. Immunostaining is enhanced by antigen retrieval with pepsin, especially paraffin tissue. Suggested positive control: basement membranes (blood vessels of any tissue, tumors, nerve).

Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Laminin
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Free Floating), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.035% sodium azide
Gene LAMC1
Gene Accession No. P02468, P02469, P07942, P11047, P19137, P24043, P25391, Q60675
Gene Alias 5830440B04; AA408497; B2e; basement membrane protein; C77966; C80098; C81607; CLM; D130003D08Rik; dy; dystrophia muscularis; LAMA; LAMA1; Lama-1; Lama2; LAMB1; Lamb-1; LAMB1; basement membrane protein; Lamb1-1; Lamb2; LAMC1; Laminin A chain; laminin alpha 2 subunit; laminin B1; laminin B1 chain; laminin B1 subunit 1; laminin B2 chain; laminin beta-1 chain; laminin gamma 1 chain; laminin M chain; laminin S; laminin subunit alpha 1; laminin subunit alpha 2; laminin subunit alpha-1; Laminin subunit alpha-2; laminin subunit beta 1; laminin subunit beta-1; laminin subunit gamma 1; laminin subunit gamma-1; laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, beta 2; laminin, gamma 1; laminin, gamma 1 (formerly LAMB2); laminin-1; laminin-1 subunit alpha; Laminin-1 subunit beta; laminin-1 subunit gamma; Laminin-10 subunit beta; laminin-10 subunit gamma; Laminin-11 subunit gamma; laminin-12 subunit alpha; Laminin-12 subunit beta; laminin-2 subunit alpha; Laminin-2 subunit beta; laminin-2 subunit gamma; Laminin-3 subunit alpha; laminin-3 subunit gamma; Laminin-4 subunit alpha; laminin-4 subunit gamma; Laminin-6 subunit beta; laminin-6 subunit gamma; Laminin-7 subunit gamma; laminin-8 subunit beta; Laminin-8 subunit gamma; laminin-9 subunit gamma; LAMM; LIS5; LOW QUALITY PROTEIN: laminin subunit alpha-1; LOW QUALITY PROTEIN: laminin subunit alpha-2; LOW QUALITY PROTEIN: laminin subunit beta-1; mer; merosin; merosin heavy chain; mKIAA4087; PTBHS; S-LAM alpha; S-LAM gamma; S-LAM-alpha; S-laminin subunit alpha; S-laminin subunit gamma
Gene Symbols LAMA1, LAMA2, LAMB1, LAMC1
Host Species Rabbit
Immunogen Laminin 111 isolated from mouse Engelbreth-Holm-Swarm (EHS) sarcoma cells.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100350500, 100357482, 100358679, 100757343, 100761564, 100765555, 101102692, 101105588, 101105743, 101117424, 103346447, 117036, 16772, 16773, 16777, 226519, 284217, 298941, 309368, 316758, 3908, 3912, 3915
Target Species Human, Mouse, Rat, Rabbit, Sheep, Hamster, Mammalia, Invertebrate
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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