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Invitrogen™ LIF Polyclonal Antibody
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Product Code. 16332065
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Quantity:
100 μL
Unit Size:
100µL
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16332065 100 μL 100µL
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Product Code. 16332065 Supplier Invitrogen™ Supplier No. PA585116

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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Dog (91%), Pig (87%), Rabbit (90%), Bovine (88%). Positive Control: 293T, A431, HeLa, HepG2, HUVEC. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIF
Applications Western Blot
Classification Polyclonal
Concentration 1.07 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Lif
Gene Accession No. P15018
Gene Alias CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Gene Symbols Lif
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human LIF. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3976
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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