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LIME1 Monoclonal Antibody (OTI9E9), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA807655
This item is not returnable.
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Description
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.Specifications
| LIME1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9H400 | |
| LIME1 | |
| Human recombit protein fragment corresponding to amino acids 30-295 of human LIME1 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI9E9 | |
| Unconjugated | |
| LIME1 | |
| LIME, dJ583P15.4 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 54923 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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