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LIN7B Monoclonal Antibody (OTI1C1), TrueMAB™, OriGene

Product Code. 17514361
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100 μL
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17514361 100 μL 100µL
17534361 30 μL 30µL
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Product Code. 17514361 Supplier Origene Technologies Supplier No. TA501479

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Description

Mouse Monoclonal Antibody

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

Specifications

Antigen LIN7B
Applications Western Blot
Classification Monoclonal
Clone OTI1C1
Concentration 0.79 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene LIN7B
Gene Accession No. Q9HAP6
Gene Alias LIN-7B, MALS-2, MALS2, VELI2
Gene Symbols LIN7B
Host Species Mouse
Immunogen Full length human recombit protein of human LIN7B produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64130
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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