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Invitrogen™ LRRK2 Monoclonal Antibody (N138/6), APC
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA545644
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Description
83% identical in mouse and rat. No significant identity with LRRK1. 1 μg/mL of MA5-45644 was sufficient for detection of LRRK2/Dardarin in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects >200kDa. This antibody was formerly sold as clone S138-6.
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
Specifications
| LRRK2 | |
| Monoclonal | |
| 1 mg/mL | |
| 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4 | |
| Q5S006, Q5S007 | |
| LRRK2 | |
| Fusion protein, amino acids 1-500 (N-terminus) of human LRRK2. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Western Blot, Immunocytochemistry | |
| N138/6 | |
| APC | |
| LRRK2 | |
| 4921513O20Rik; 9330188B09Rik; augmented in rheumatoid arthritis 17; AURA17; AW561911; BC 300-268; cI-46; D630001M17Rik; DARDARIN; DKFZp434H2111; FLJ45829; Gm927; leucine rich repeat kinase 2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; Lrrk2; LRRK-2; PARK8; RIPK7; ROCO2 | |
| Mouse | |
| Protein G | |
| RUO | |
| 120892, 300160, 66725 | |
| 4°C | |
| Liquid |
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