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Invitrogen™ LRRK2 Monoclonal Antibody (N231B/34), APC
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Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA545641

Product Code. 17858432

  • € 455.00 / 100µg

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Description

Description

81% identical in mouse, 80% identical in rat. <30% identity with LRRK1. 10 μg/mL of MA5-45641 was sufficient for detection of LRRK2/Dardarin in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects >200kDa. This antibody was formerly sold as clone S231B-34.

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LRRK2
Monoclonal
1 mg/mL
2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Q5S007
LRRK2
Fusion protein amino acids 841-960 of human LRRK2.
100 μg
Primary
Human, Rat
Antibody
IgG2a
Immunohistochemistry, Western Blot, Immunocytochemistry
N231B/34
APC
LRRK2
4921513O20Rik; 9330188B09Rik; augmented in rheumatoid arthritis 17; AURA17; AW561911; BC 300-268; cI-46; D630001M17Rik; DARDARIN; DKFZp434H2111; FLJ45829; Gm927; leucine rich repeat kinase 2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; Lrrk2; LRRK-2; PARK8; RIPK7; ROCO2
Mouse
Protein G
RUO
120892, 300160
4°C
Liquid
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