Invitrogen™ LUM Polyclonal Antibody

Description

Positive test controls include: A-549, HepG2, Mouse heart, Mouse lung, Rat heart, Rat lung. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space. Immunogen sequence: QYYDYDFPLS IYGQSSPNCA PECNCPESYP SAMYCDELKL KSVPMVPPGI KYLYLRNNQI DHIDEKAFEN VTDLQWLILD HNLLENSKIK GRVFSKLKQL KKLHINHNNL TESVGPLPKS LEDLQLTHNK ITKLGSFEGL VNLTFIHLQH NRLKEDAVSA AFKGLKSLEY LDLSFNQIAR LPSGLPVSLL TLYLDNNKIS NIPDEYFKRF NALQYLRLSH NELADSGIPG NSFNVSSLVE LDLSYNKLKN IPTVNENLEN YYLEVNQLEK FDIKSFCKIL GPLSYSKIKH LRLDGNRISE TSLPPDMYEC LRVANEVTLN.

LUM is a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, this protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. The protein is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.