missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ LXR alpha Recombinant Rabbit Monoclonal Antibody (7Z4H10)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA542842
This item is not returnable.
View return policy
Description
Positive test controls include: 293T, HepG2, Mouse liver, Mouse kidney, Mouse stomach, Rat liver. The target is usually found in the following locations: Nucleus. Immunogen sequence: MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV.
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
Specifications
| LXR alpha | |
| Recombinant Monoclonal | |
| 0.25 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q13133, Q62685, Q9Z0Y9 | |
| NR1H3 | |
| Synthetic peptide | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 7Z4H10 | |
| Unconjugated | |
| NR1H3 | |
| AU018371; liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR; LXR alpha; Lxra; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 10062, 22259, 58852 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction