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Invitrogen™ LYK5 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA587821
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Description
Immunogen sequence: FLPEGGCYEL LTVIGKGFED LMTVNLARYK PTGEYVTVRR INLEACSNEM VTFLQGELHV SKLFNHPNIV PYRATFIADN ELWVVTSFMA YGSAKDLICT HFMDGMNELA IAYILQGVLK ALDYIHHMGY VHRSVKASHI LISVDGKVYL SGLRSNLSMI SHGQRQRVVH DFPKYSVKVL PWLSPE; Positive Samples: Mouse skeletal muscle; Cellular Location: Cytoplasm, Nucleus.
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
Specifications
| LYK5 | |
| Polyclonal | |
| Unconjugated | |
| STRADA | |
| 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; LYK5; NY-BR-96; PMSE; protein kinase LYK5; serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STE20-related kinase adaptor alpha; Stlk; Strad; STRAD alpha; Strada | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 72149 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot | |
| 1.98 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q3UUJ4 | |
| STRADA | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_6991662). | |
| 100 μL | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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