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Invitrogen™ MAP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5112255
This item is not returnable.
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Description
MAP1 Polyclonal Antibody for Western Blot, IHC (P)
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
Specifications
| MAP1 | |
| Polyclonal | |
| Unconjugated | |
| MOAP1 | |
| AA987038; MAP1; Map-1; Moap1; Modulator of apoptosis 1; paraneoplastic antigen like 4; paraneoplastic antigen Ma4; paraneoplastic Ma antigen family member 4; PNMA4 | |
| Rabbit | |
| Antigen Affinity Chromatography, Protein A | |
| RUO | |
| 64112 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 0.03% ProClin 300; pH 7 | |
| Q96BY2 | |
| MOAP1 | |
| E. coli-derived Human MAP1/MOAP1 fragment. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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