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  4. Invitrogen™ Human MAPK14 (p38 alpha), GST Tag Recombinant Protein

Invitrogen™ Human MAPK14 (p38 alpha), GST Tag Recombinant Protein

Product Code. 11573417
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Quantity:
10 μg
Unit Size:
10µg
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Product Code. 11573417

Brand: Invitrogen™ PV3304

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This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Full Length.

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q16539
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 20mM tris with 2mM DTT, 0.5mM EDTA, 50% glycerol, 150mM NaCl, 0.01% Triton X-100 and no preservative; pH 7.5
Gene ID (Entrez) 1432
Molecular Weight (g/mol) 67.6 kDa
Name Human MAPK14 (p38 alpha), GST Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 186F5S; anon-sts23; BG:DS00797.3; CG7393; CG7393-PA; CRK1; CSAID-binding protein; Csaids binding protein; CSBP; Csbp1; Csbp2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; cytokine suppressive anti-inflammatory drug-binding protein; cytokine-supressive anti-inflammatory drug binding protein; Dm p38b; Dmel\CG7393; Dmel_CG7393; Dmp38b; Dp38; D-p38; D-p38 MAPK; Dp38b; D-p38b; EC 2.7.11.24; ERK1; ERT2; ESTS:186F5S; etID18993.8; Exip; fk28c03; hm:zeh1243; Hog; I79_016605; LD24658p; MAP 14; MAP kinase 1; MAP kinase 11; MAP kinase 14; MAP kinase 14A; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38; MAP kinase p38 alpha; MAP kinase p38 beta; MAP kinase p38a; MAP kinase p38alpha; MAP kinase p38b; MAPK; MAPK 11; MAPK 14; MAPK 14A; MAPK1 antibody; Mapk11; Mapk14; mapk14a; MAX-interacting protein 2; mitogen activated protein kinase 11; mitogen activated protein kinase 14; mitogen-activated protein kinase 11; Mitogen-activated protein kinase 14; mitogen-activated protein kinase 14a; Mitogen-activated protein kinase p38 alpha; mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; mitogen-activated protein kinase p38a; Mitogen-activated protein kinase p38b; MK14; Mpk34C; Mxi2; OTTHUMP00000216563; OTTHUMP00000216566; P38; p38 alpha; p38 alpha/Mxi2; p38 beta; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38 mitogen-activated protein kinase; p38-2; p38a; p38ALPHA; p38-alpha; p38alpha Exip; P38B; p38b MAP kinase; p38beta; p38beta2; p38b-PA; p38Hog; p38Kb; p38MAPK; PRKM11; Prkm14; Prkm15; protein kinase, mitogen activated kinase, 11, p38beta; reactive kinase; RK; RP1-179N16.5; Sapk2; Sapk2A; SAPK2b; stress-activated p38b MAP kinase; stress-activated protein kinase 2A; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b; tRNA synthetase cofactor p38; wu:fk28c03; zeh1243; zp38a
Common Name p38 MAPK alpha
Gene Symbol MAPK14
KinaseFamily MAP Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Ser⁄Thr Kinases: CMGC Group
Shipping Condition Dry Ice
System Compatibility LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Target Entry MAPK14
Target Gene mitogen-activated protein kinase 14
Expression System E. coli
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Protein Subtype Serine/Threonine Kinases
Research Category Signal Transduction
Purity or Quality Grade 95% by SDS-PAGE
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