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  6. 15951835

Invitrogen™ MAPK15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA575309

Product Code. 15951835

  • € 520.00 / 100µL

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Description

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MAPK15
Polyclonal
Unconjugated
MAPK15
BC048082; EC 2.7.11.24; ERK7; ERK-7; ERK8; ERK-8; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; Mapk15; Mitogen-activated protein kinase 15
Rabbit
Antigen affinity chromatography
RUO
225689, 286997, 332110
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Q80Y86, Q8TD08, Q9Z2A6
MAPK15
Synthetic peptide corresponding to amino acids 140-190 of Human MAPK15.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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