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MAPK8IP1 Monoclonal Antibody (OTI8H5), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA809901
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Beskrivelse
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.Tekniske data
| MAPK8IP1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9UQF2 | |
| MAPK8IP1 | |
| Full length human recombit protein of human MAPK8IP1 produced in HEK293T cell. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI8H5 | |
| Unconjugated | |
| MAPK8IP1 | |
| IB1, JIP-1, JIP1, PRKM8IP | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 9479 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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