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Invitrogen™ Matuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (Matuzumab)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA547998
This item is not returnable.
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Description
Specificity: This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding. This antibody can only recognize the active form of EGFR. The antibody binds to both glyco- and aglyco receptor forms.
Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR, frequently associated with the growth of blood vessels in malignancy, facilitating tumor growth and survival.
Specifications
| Matuzumab Chimeric | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| P10300 | |
| Rabbit | |
| Protein A | |
| RUO | |
| 12526 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| ELISA, Flow Cytometry, Functional Assay, Inhibition Assays, Western Blot, Immunocytochemistry | |
| Matuzumab | |
| Unconjugated | |
| Cd8b1 | |
| EMD-72000; H425 | |
| Domain III of the extracellular domain of human EGRF. | |
| 200 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG κ |
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