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Invitrogen™ MCM10 Polyclonal Antibody
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Product Code. 15778931 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15778931 100 μL 100µL
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Product Code. 15778931 Supplier Invitrogen™ Supplier No. PA561117

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QTTLSNLVVK GTNLIIQETR QKLGIPQKSL SCSEEFKELM DLPTCGARNL KQHLAKATAS GIMGSPKPAI KSISASALLK QQKQRMLEMR RRKSEEIQK Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 79%.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MCM10
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MCM10
Gene Accession No. Q7L590
Gene Alias 2410041F14Rik; AU018508; C330019M07Rik; C79164; CNA43; DNA43; homolog of yeast MCM10; hsMCM10; Mcm10; MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance 10 replication initiation factor; minichromosome maintenance complex component 10; minichromosome maintenance deficient 10; minichromosome maintenance deficient 10 (S. cerevisiae); PRO2249; Protein MCM10 homolog
Gene Symbols MCM10
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MCM10. Recombinant protein control fragment (Product #RP-97005).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55388
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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