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Invitrogen™ MDMX Monoclonal Antibody (OTI4B5)
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Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA526195

Product Code. 15925794

  • € 570.00 / 100µL

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Description

Description

MDMX Monoclonal Antibody for ICC/IF, IHC (P)

The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MDMX
Monoclonal
1 mg/mL
PBS with 50% glycerol, 1% BSA and 0.02% sodium azide; pH 7.3
O15151
MDM4
Full length human recombinant protein of MDM4 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG1
Immunohistochemistry (Paraffin), Immunocytochemistry
OTI4B5
Unconjugated
MDM4
4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; DKFZp781B1423; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX; human homolog of; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; MDM4-related protein 1; Mdmx; MGC132766; MRP1; p53-binding protein Mdm4; Protein Mdm4; protein Mdmx; RP11-430C7.1; transformed mouse 3T3 cell double minute 4
Mouse
Affinity Chromatography
RUO
4194
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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