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  6. MDMX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

MDMX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. p-7208643 Shop All Proteintech Products
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20 μL
150 μL
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150µL
20µL
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Product Code. Quantity unitSize
16837924 20 μL 20µL
16827924 150 μL 150µL
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Product Code. 16837924 Supplier Proteintech Supplier No. 179141AP20UL

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Description

Rabbit Polyclonal Antibody

The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in maligt gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.

Specifications

Antigen MDMX
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MDM4
Gene Accession No. O15151, O35618, Q5XIN1
Gene Alias Double minute 4 protein, HDMX, Mdm2 like p53 binding protein, MDM4, MDMX, MRP1, p53 binding protein Mdm4, Protein Mdm4, Protein Mdmx
Gene Symbols Mdm4
Host Species Rabbit
Immunogen MDMX Fusion Protein Ag12319
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17248, 304798, 4194
Target Species Mouse, Rat, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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