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Invitrogen™ MDMX Recombinant Rabbit Monoclonal Antibody (BL-3-2F2)
Rabbit Recombinant Monoclonal Antibody
€ 148.00 - € 376.00
Specifications
| Antigen | MDMX |
|---|---|
| Clone | BL-3-2F2 |
| Concentration | 100 μg/mL |
| Content And Storage | 4°C |
| Applications | Flow Cytometry, Immunoprecipitation, Western Blot |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17735569
|
Invitrogen™
MA544197 |
100 μL |
€ 376.00
100µL |
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|
17745569
|
Invitrogen™
MA544198 |
20 μL |
€ 148.00
20µL |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
MDMX Recombinant Monoclonal Antibody for Western Blot, Flow, IP
The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.Specifications
| MDMX | |
| 100 μg/mL | |
| Flow Cytometry, Immunoprecipitation, Western Blot | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6 | |
| O15151 | |
| 4194 | |
| Region between residues 125 and 175 of human ortholog of mouse double minute 4. | |
| Antibody |
| BL-3-2F2 | |
| 4°C | |
| Recombinant Monoclonal | |
| Liquid | |
| IgG | |
| Human | |
| MDM4 | |
| 4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; DKFZp781B1423; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX; human homolog of; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; MDM4-related protein 1; Mdmx; MGC132766; MRP1; p53-binding protein Mdm4; Protein Mdm4; protein Mdmx; RP11-430C7.1; transformed mouse 3T3 cell double minute 4 | |
| MDM4 | |
| Primary | |
| purified |
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