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Invitrogen™ ME2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA538007
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Description
A recommended positive control is human spleen tissue lysate. At least two isoforms of ME2 are known to exist; this antibody will detect both isoforms. ME2 antibody is not expected to cross-react with ME1.
ME2 encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.
Specifications
| ME2 | |
| Polyclonal | |
| Unconjugated | |
| Me2 | |
| AW120568; D030040L20Rik; malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating); malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; Me2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 4200 | |
| Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| P23368 | |
| Me2 | |
| 17 amino acid peptide near the center of human ME2. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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