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Invitrogen™ MECR Polyclonal Antibody
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Product Code. 15782481 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15782481 100 μL 100µL
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Product Code. 15782481 Supplier Invitrogen™ Supplier No. PA554553

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SDIPLQSAAT LGVNPCTAYR MLMDFEQLQP GDSVIQNASN SGVGQAVIQI AAALGLRTIN VVRDRPDIQK LSDRLKSLGA EHVITEEELR RPEMKNFFKD MPQPRLALNC V Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.

The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MECR
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Mecr
Gene Accession No. Q9BV79
Gene Alias 2-enoyl thioester reductase; AI195831; CGI-63; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; FASN2B; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; Mecr; mitochondrial 2-enoyl thioester reductase; mitochondrial trans-2-enoyl-CoA reductase; NBRF1; Nrbf1; NRBF-1; nuclear receptor binding factor 1; nuclear receptor-binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial
Gene Symbols Mecr
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MECR. Recombinant protein control fragment (Product #RP-93135).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51102
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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