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Tocris Bioscience™ Mefloquine hydrochloride
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Product Code. 18777656
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50 mg
Unit Size:
50mg
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18777656 50 mg 50mg
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Product Code. 18777656 Supplier Tocris Bioscience™ Supplier No. 6819/50

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Description

Cx36 and Cx50 gap channel blocker

Mefloquine hydrochloride is a Cx36 and Cx50 gap channel blocker (IC50 values are 0.3 and 1.1 μM, resepctively). Blocks gap junctional-coupling between interneurons in neocortical slices. Also antimalarial. Bind 80S ribosome of Plasmodium falciparum to inhibit protein synthesis. Improves survival in P berghei-infected mice. Additionally exhibits antischistosomal activity in vitro and in vivo. Exhibits antiviral activities against SARS-CoV-2 (IC50 < 10 μM).
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Specifications

Chemical Name or Material (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride
CAS 51773-92-3
Quantity 50 mg
Molecular Formula C17H16F6N2O.HCl
Formula Weight 414.77
Purity 98%
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