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MET Monoclonal Antibody (OTI1A8), TrueMAB™, OriGene

Product Code. 17566043
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17566043 100 μL 100µL
17586043 30 μL 30µL
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Product Code. 17566043 Supplier Origene Technologies Supplier No. TA805996

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Description

Mouse Monoclonal Antibody

MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

Specifications

Antigen MET
Applications Western Blot
Classification Monoclonal
Clone OTI1A8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene MET
Gene Accession No. P08581
Gene Alias AUTS9, DFNB97, HGFR, RCCP2, c-Met
Gene Symbols MET
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 570-885 of human MET produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4233
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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