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Invitrogen™ Metadherin Monoclonal Antibody (6-F4)
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Product Code. 17286673 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17286673 100 μL 100µL
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Product Code. 17286673 Supplier Invitrogen™ Supplier No. MA537800

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Description

Mouse Monoclonal Antibody

Positive controls: MCF-7 cell lysate, Jurkat cell lysate, Hela cell lysate, K562.

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
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Specifications

Antigen Metadherin
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 6-F4
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene MTDH
Gene Accession No. Q86UE4
Gene Alias 2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
Gene Symbols MTDH
Host Species Mouse
Immunogen Recombinant protein within Human LYRIC aa 6-233.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92140
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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