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Invitrogen™ MINA53 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA531229
This item is not returnable.
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Description
Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Human (99%), Rat (80%), Rhesus Monkey (98%), Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
Specifications
| MINA53 | |
| Polyclonal | |
| Unconjugated | |
| RIOX2 | |
| 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; 60S ribosomal protein L27a histidine hydroxylase; AI449204; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; histone lysine demethylase MINA; MDIG; mina; mina {ECO:0000312; Mina53; Mina-53; mineral dust induced gene protein; mineral dust-induced gene protein; MYC induced nuclear antigen; myc-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; NO52; Nucleolar protein 52; Protein mina53; RGD:708521}; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; RIOX2; ROX | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 84864 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q8IUF8 | |
| RIOX2 | |
| Recombinant protein encompassing a sequence within the center region of human MINA53. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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