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Invitrogen™ MiTF Recombinant Rabbit Monoclonal Antibody (6S9G4)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA551329
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Descripción
Immunogen sequence: HGLSLIPSTG LCSPDLVNRI IKQEPVLENC SQDLLQHHAD LTCTTTLDLT DGTITFNNNL GTGTEANQAY SVPTKMGSKL EDILMDDTLS PVGVTDPLLS SVSPGASKTS SRRSSMSMEE TEHTC.
Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.
Especificaciones
| MiTF | |
| Recombinant Monoclonal | |
| 0.227 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| O75030, O88368 | |
| MITF | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 402-526 of human MITF (NP_001341533.1). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry | |
| 6S9G4 | |
| Unconjugated | |
| MITF | |
| BCC2; Bhlhe32; black eyed white; bw; Class E basic helix-loop-helix protein 32; CMM8; Gsfbcc2; melanocyte inducing transcription factor; melanogenesis associated transcription factor; mi; microphtalmia-associated transcription factor; microphthalmia; microphthalmia associated transcription factor isoform M-; microphthalmia transcription factor; microphthalmia-associated transcription factor; microphthalmia-associated transcription factor A; microphthalmia-associated transcription factor isoform H; microphthalmia-associated transcription factor isoform H protein; microphthalmia-associated transcription factor Trnc-1; microphthalmia-associated transcription factor Trnc-2; microphthalmia-associated transcription factor variant 1; microphthalmia-associated transcription factor variant 2; microphthalmia-associated transcription factor variant 3; microphthalmia-associated transcription factor variant MITF-M(+); MITF; MITF-H; MITF-M; MITF-M-; transcription factor, isoform 7; vit; Vitiligo; Wh; WS2; WS2A | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 25094, 4286 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid | |
| IgG |
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