Invitrogen™ MKP3 Polyclonal Antibody

Description

Positive test controls include: HT-29, 293T. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: TVTVAYLMQK LNLSMNDAYD IVKMKKSNIS PNFNFMGQLL DFERTLGLSS PCDNRVPAQQ LYFTTPSNQN VYQVDSLQST.

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.