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MLH1 Monoclonal Antibody (OTI5H2), TrueMAB™, OriGene

Product Code. 17566154
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Quantity:
30 μL
100 μL
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100µL
30µL
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Product Code. Quantity unitSize
17566154 100 μL 100µL
17586154 30 μL 30µL
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Product Code. 17566154 missing translation for 'mfr' Origene Technologies missing translation for 'supplierNo' TA811844

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Description

Mouse Monoclonal Antibody

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Specifications

Antigen MLH1
Applications Western Blot
Classification Monoclonal
Clone OTI5H2
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene MLH1
Gene Accession No. P40692
Gene Alias COCA2, FCC2, HNPCC, HNPCC2, hMLH1
Gene Symbols MLH1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-298 of human MLH1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4292
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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