MMP1 Monoclonal Antibody (6A5), Invitrogen™

Description

MA5-15872 targets MMP1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human samples. The MA5-15872 immunogen is purified recombinant fragment of human MMP1 expressed in E. Coli. . MA5-15872 detects MMP1 which has a predicted molecular weight of approximately 54kDa.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.