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Invitrogen™ MMP8 Monoclonal Antibody (C8)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA541639
This item is not returnable.
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Description
MMP8 Monoclonal Antibody for ICC/IF, IHC (P), Western Blot
The MMP8 gene encodes matrix metalloproteinase-8, also known as collagenase-2, an enzyme belonging to the matrix metalloproteinase (MMP) family, which plays a pivotal role in the breakdown of extracellular matrix (ECM) components. MMP8 is primarily involved in the degradation of type I and III collagen, facilitating tissue remodeling and repair processes. This enzyme is produced by neutrophils and is active in areas of tissue inflammation and injury, where it modulates the ECM to aid in wound healing. MMP8 is implicated in various physiological processes, including embryonic development, angiogenesis, and bone remodeling. However, excessive or unregulated activity of MMP8 can lead to pathological conditions such as arthritis, periodontal disease, and cancer metastasis, where ECM degradation contributes to disease progression. Research into MMP8 aims to understand its regulation and involvement in disease states, providing insights into potential therapeutic strategies for targeting MMP activity in inflammatory and degenerative conditions.
Specifications
| MMP8 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4 | |
| P22894 | |
| MMP8 | |
| Recombinant protein Matrix Metalloproteinase 8. The antigen corresponds to amino acid range 101-467 of the target protein. | |
| 200 μL | |
| Primary | |
| Human, Pig | |
| Antibody | |
| IgG2a κ |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| C8 | |
| Unconjugated | |
| MMP8 | |
| BB138268; CLG1; Collagenase; Collagenase 2; collagenase-2; HNC; matrix metallo protease; matrix metallopeptidase 8; matrix metallopeptidase 8 (neutrophil collagenase); matrix metalloproteinase 8; matrix metalloproteinase 8 (neutrophil collagenase); Matrix metalloproteinase8; matrix metalloproteinase-8; MMP; MMP 8; Mmp8; MMP-8; MMPs; Neutrophil collagenase; neutrophil collagenease; PMN leukocyte collagenase; PMNL CL; PMNL collagenase; PMNLCL; PMNL-CL | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 100523811, 4317 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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