Invitrogen™ CD122/CD132 Biosimilar Recombinant Monoclonal Antibody

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °. This antibody can also be cross referenced by the term Singapore ASTR patent anti-IL-2R beta/IL-2R gamma .

CD122 and CD132 are integral subunits of the interleukin-2 receptor (IL-2R) complex, which also includes the alpha chain (CD25). They are respectively known as the beta chain (CD122) and the gamma chain (CD132). These genes are expressed in various cell types and are crucial for immunological responses. The heterodimeric CD122/CD132 receptor subunits are vital for the signal transduction of interleukins like IL-2 and IL-15, which are critical for T cell proliferation and activation. CD122, in particular, has an extensive intracellular region, making it indispensable for downstream signaling. Both CD122 and CD132 contribute to the receptor's function by binding IL-2 and other cytokines, facilitating their role in immune regulation and homeostasis. Studies suggest that CD122 and CD132 may be expressed by fibroblast-like synoviocytes (FLS) and dermal fibroblasts (DF), underscoring their broader biological significance beyond immune cells. This receptor complex is also a focal point in cancer immunotherapy strategies due to its role in modulating T regulatory cells (Tregs) and effector T cells.