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MORF4 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI5F2, lyophilized, TrueMAB™

Product Code. 17606041
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Quantity:
100 μg
Unit Size:
100µg
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17606041 100 μg 100µg
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Product Code. 17606041 Supplier Origene Technologies Supplier No. CF800378

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.

Specifications

Antigen MORF4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI5F2
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene MORF4
Gene Accession No. Q5M820, Q9CQL7
Gene Alias CSR, CSRB, SEN, SEN1
Gene Symbols MORF4, Mrfap1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-255 of human MORF4 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10934, 282585, 67568
Target Species Canine, Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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