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CD45R, Mouse, Clone: 351C5, Abnova™
Mouse monoclonal antibody raised against native CD45R.
Brand: Abnova MAB6954.100ug
This item is not returnable.
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Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Specifications
| CD45R | |
| Monoclonal | |
| Unconjugated | |
| The optimal working dilution should be determined by the end user. | |
| PTPRC | |
| PTPRC | |
| Native purified CD45R from peripheral blood mononuclear cells. | |
| RUO | |
| 5788 | |
| Store at 4°C. | |
| IgM |
| Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation | |
| 351C5 | |
| Mouse monoclonal antibody raised against native CD45R. | |
| In 50mM sodium phosphate buffer, 100mM potassium chloride, 150mM NaCl, pH 7.5 (0.5mg/mL gentamicin sulfate) | |
| B220/CD45/CD45R/GP180/LCA/LY5/T200 | |
| Mouse | |
| 100 μg | |
| Primary | |
| Human | |
| Liquid |
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