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CD46, Mouse, APC, Clone: MEM-258, Abnova™

Product Code. 16056276
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100 Reactions
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100 reactions
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16056276 100 Reactions 100 reactions
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Product Code. 16056276 Supplier Abnova Supplier No. MAB4439.100Reactions

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Description

Mouse monoclonal antibody raised against native CD46.

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen CD46
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone MEM-258
Conjugate APC
Description Mouse monoclonal antibody raised against native CD46.
Dilution Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.2% BSA, 0.09% sodium azide)
Gene CD46
Gene Alias MCP/MGC26544/MIC10/TLX/TRA2.10
Gene Symbols CD46
Host Species Mouse
Immunogen Native purified CD46 from human T cell line HPB-ALL.
Quantity 100 Reactions
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4179
Test Specificity This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 KDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Target Species Bovine, Human
Content And Storage Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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